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Rhodes, Christopher
One or more keywords matched the following items that are connected to Rhodes, Christopher
Item TypeName
Concept Blood Proteins
Concept DNA-Binding Proteins
Concept Eye Proteins
Concept Membrane Proteins
Concept Nerve Tissue Proteins
Concept Monosaccharide Transport Proteins
Concept Muscle Proteins
Concept Protein Precursors
Concept Protein-Tyrosine Kinases
Concept Protein Binding
Concept Protein Conformation
Concept Protein Processing, Post-Translational
Concept Proto-Oncogene Proteins
Concept Proteins
Concept Repressor Proteins
Concept Protein Kinases
Concept Protein Biosynthesis
Concept Protein Engineering
Concept rac1 GTP-Binding Protein
Concept Mitogen-Activated Protein Kinases
Concept Protein Subunits
Concept Extracellular Matrix Proteins
Concept HMGA1a Protein
Concept Milk Proteins
Concept Cysteine Proteinase Inhibitors
Concept Proto-Oncogene Proteins c-fos
Concept Cyclic AMP Response Element-Binding Protein
Concept Protein Structure, Tertiary
Concept Amyloid beta-Protein Precursor
Concept RNA-Binding Proteins
Concept Immediate-Early Proteins
Concept Insulin-Like Growth Factor Binding Protein 1
Concept ras Proteins
Concept Qa-SNARE Proteins
Concept Bone Morphogenetic Protein Receptors, Type II
Concept Receptor Protein-Tyrosine Kinases
Concept Protein Transport
Concept Protein Folding
Concept HMGB Proteins
Concept Mitochondrial Proteins
Concept Intercellular Signaling Peptides and Proteins
Concept Receptors, G-Protein-Coupled
Concept Green Fluorescent Proteins
Concept Mutant Chimeric Proteins
Concept Protein Kinase C-delta
Concept Mitogen-Activated Protein Kinase 3
Concept Ribosomal Protein S6 Kinases
Concept Proto-Oncogene Proteins c-raf
Concept SNARE Proteins
Concept Cell Cycle Proteins
Concept rab3 GTP-Binding Proteins
Concept Bone Morphogenetic Proteins
Concept I-kappa B Proteins
Concept rab3A GTP-Binding Protein
Concept Oncogene Protein v-akt
Concept Saccharomyces cerevisiae Proteins
Concept Protein Kinase C-epsilon
Concept Protein Kinase C
Concept Recombinant Proteins
Concept Bone Morphogenetic Protein 4
Concept Shc Signaling Adaptor Proteins
Concept Calcitonin Receptor-Like Protein
Concept Sterol Regulatory Element Binding Protein 1
Concept Adaptor Proteins, Signal Transducing
Concept R-SNARE Proteins
Concept HSP40 Heat-Shock Proteins
Concept Vesicle-Associated Membrane Protein 3
Concept Inhibitor of Differentiation Protein 1
Concept Bone Morphogenetic Protein Receptors, Type I
Concept Viral Proteins
Concept GTP-Binding Proteins
Concept Mitogen-Activated Protein Kinase 1
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept cdc42 GTP-Binding Protein
Concept Son of Sevenless Protein, Drosophila
Concept Homeodomain Proteins
Concept Cation Transport Proteins
Concept Monomeric GTP-Binding Proteins
Concept GTPase-Activating Proteins
Concept Protein Sorting Signals
Concept JNK Mitogen-Activated Protein Kinases
Concept GRB2 Adaptor Protein
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 1
Concept AMP-Activated Protein Kinases
Concept Bone Morphogenetic Protein 6
Concept Insulin Receptor Substrate Proteins
Concept Ribosomal Protein S6 Kinases, 70-kDa
Concept Protein Interaction Maps
Concept Intracellular Signaling Peptides and Proteins
Concept Suppressor of Cytokine Signaling Proteins
Concept Protein Kinase C-alpha
Concept ADAM Proteins
Concept Amyloid Precursor Protein Secretases
Concept Agouti-Related Protein
Concept Calcium-Binding Proteins
Concept Carrier Proteins
Concept Cytoskeletal Proteins
Concept Luminescent Proteins
Concept Nuclear Proteins
Concept Recombinant Fusion Proteins
Concept Tumor Suppressor Protein p53
Concept Cyclic AMP-Dependent Protein Kinases
Concept Protein Isoforms
Concept Membrane Transport Proteins
Concept Vesicular Transport Proteins
Concept Adaptor Proteins, Vesicular Transport
Concept Protein Kinase Inhibitors
Concept p38 Mitogen-Activated Protein Kinases
Concept Proto-Oncogene Proteins c-akt
Concept Bone Morphogenetic Protein Receptors
Concept Receptor-Like Protein Tyrosine Phosphatases, Class 8
Academic Article Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
Academic Article Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases.
Academic Article A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.
Academic Article Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
Academic Article Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
Academic Article Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.
Academic Article Insulin-secreting non-islet cells are resistant to autoimmune destruction.
Academic Article The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs.
Academic Article Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
Academic Article Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
Academic Article A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
Academic Article Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
Academic Article Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
Academic Article Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
Academic Article Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.
Academic Article Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
Academic Article Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
Academic Article Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
Academic Article Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.
Academic Article Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
Academic Article Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
Academic Article Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
Academic Article A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis.
Academic Article Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
Academic Article Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats.
Academic Article Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
Academic Article Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
Academic Article Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
Academic Article Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells.
Academic Article Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
Academic Article Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
Academic Article Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population.
Academic Article A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
Academic Article Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
Academic Article Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
Academic Article Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
Academic Article Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.
Academic Article Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.
Academic Article Type 2 diabetes-a matter of beta-cell life and death?
Academic Article Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells.
Academic Article Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
Academic Article Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
Academic Article Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.
Academic Article Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
Academic Article Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
Academic Article Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
Academic Article Proinsulin maturation, misfolding, and proteotoxicity.
Academic Article A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
Academic Article Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.
Academic Article Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells.
Academic Article Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
Academic Article Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules.
Academic Article [Biogenesis of the insulin secretion granule].
Academic Article Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
Academic Article Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.
Academic Article The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
Academic Article Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
Academic Article Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets.
Academic Article Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
Academic Article Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance.
Academic Article Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
Academic Article Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
Academic Article Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
Academic Article AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.
Academic Article Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.
Academic Article Degradation of islet amyloid polypeptide by neprilysin.
Academic Article Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases.
Academic Article Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets.
Academic Article FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
Academic Article A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
Academic Article What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism.
Academic Article Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
Academic Article PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
Academic Article Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
Academic Article Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
Academic Article Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
Academic Article Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
Academic Article IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
Academic Article Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.
Academic Article Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.
Academic Article Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
Academic Article Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.
Academic Article Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function.
Academic Article Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet.
Academic Article Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
Academic Article Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Academic Article Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
Academic Article Intracellular signalling. Key enzyme in leptin-induced anorexia.
Academic Article A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake.
Academic Article Islet autoantigens: structure, function, localization, and regulation.
Academic Article Characterization of the promoter for the rat and human link protein gene.
Academic Article Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.
Academic Article Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells.
Academic Article Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
Academic Article Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
Academic Article RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Academic Article SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ß cells.
Academic Article In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and Its Target Slug.
Academic Article Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus.
Academic Article Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
Academic Article Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-ß in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
Academic Article Ca(2+)-regulated serine protease associated with the nuclear scaffold.
Academic Article Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini.
Academic Article The c-propeptide of type II procollagen binds to the enhancer region of the type II procollagen gene and regulates its transcription.
Academic Article BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFß-TAK1-MAPK pathways in PAH.
Academic Article Characterization of a glucocorticoid responsive element and identification of an AT-rich element that regulate the link protein gene.
Academic Article Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits.
Academic Article Leptin action in the forebrain regulates the hindbrain response to satiety signals.
Academic Article Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension.
Academic Article An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.
Academic Article Spatial organization of EphA2 at the cell-cell interface modulates trans-endocytosis of ephrinA1.
Academic Article Exclusion of human proteoglycan link protein (CRTL1) and type II collagen (COL2A1) genes in pseudoachondroplasia.
Academic Article Essential Role for Hypothalamic Calcitonin Receptor?Expressing Neurons in the Control of Food Intake by Leptin.
Academic Article Fluorometric assay of a calcium-dependent, paired-basic processing endopeptidase present in insulinoma granules.
Academic Article Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights.
Academic Article Alternative splicing generates two different mRNA species for rat link protein.
Academic Article Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future.
Academic Article Therapeutic targets in pulmonary arterial hypertension.
Academic Article The human genome contains a pseudogene for the Mr=32,000 laminin binding protein.
Academic Article Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
Academic Article Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study.
Academic Article Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.
Academic Article PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE.
Academic Article Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
Academic Article The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension.
Academic Article Unsuitability of indoxyl acetate as a substrate for the assay of testicular hyaluronidase.
Academic Article Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.
Academic Article Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
Academic Article Targeted Measurements of O- and N-Glycopeptides Show That Proteins in High Density Lipoprotein Particles Are Enriched with Specific Glycosylation Compared to Plasma.
Academic Article Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension.
Academic Article Targeting Vessel Formation in Pulmonary Arterial Hypertension: Is the Endostatin-Id1-Thrombospondin 1 Pathway a New Hope?
Academic Article The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti.
Academic Article Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
Academic Article A fluorescent timer reporter enables sorting of insulin secretory granules by age.
Academic Article A genetic map of the mouse dorsal vagal complex and its role in obesity.
Academic Article BAd-CRISPR: Inducible gene knockout in interscapular brown adipose tissue of adult mice.
Academic Article Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension.
Academic Article Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life.
Academic Article PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Concept Forkhead Box Protein O1
Concept Suppressor of Cytokine Signaling 3 Protein
Concept ADAM10 Protein
Concept ADAMTS13 Protein
Concept Uncoupling Protein 1
Concept Forkhead Box Protein O3
Concept Src Homology 2 Domain-Containing, Transforming Protein 1
Concept Serrate-Jagged Proteins
Concept Jagged-1 Protein
Concept Short Stature Homeobox Protein
Concept Regulatory-Associated Protein of mTOR
Concept Protein Kinase C beta
Concept 3-Phosphoinositide-Dependent Protein Kinases
Grant Mitogenic Signal Transduction in Pancreatic Beta-Cells
Grant Metabolic Control of Insulin Exocytosis
Grant Metabolic Control of Proinsulin Biosynthesis Translation
Grant Metabolic Control of Proinsulin Biosynthesis Translation
Academic Article SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.
Academic Article Response by Walters et al to Letter Regarding Article, "SOX17 Enhancer Variants Disrupt Transcription Factor Binding and Enhancer Inactivity Drives Pulmonary Hypertension".
Academic Article Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension.
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